Galilei Donna is an anime which knew very well how it wanted to begin and end, but it’s clear there was not much forethought put into the middle. There are elements in the first episode which pay off satisfyingly in the end, such as the condition of the Ferrari sisters’ mother, but the length of time in which they went largely unmentioned compromises the impact. The amount of meandering that happens in the show (and I’m not against meandering per se, it’s just that it often seemed to contradict itself), certainly did not help, and it made the whole thing feel like it should have been 5 episodes shorter.
Given this, I really feel like Galilei Donna would have benefited from being either a film, or an OVA, or something along those lines. I think one of the key issues is that the beginning and end feel too far off from each other (even though it’s only 11 episodes), and the fact that the way they go about finding the Galileo sketches seems abrupt and without much conflict around the actual objects. This is the kind of thing that would be more forgiving in a movie or maybe 1-3 episode anime where the act of searching for the sketches could be done in montage and would not lead the series to feeling like the sketches had no true narrative weight to them. Also, when the conclusion is only 90 minutes away, it would not feel like the middle was largely wasted.